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目的:观察痛泄Ⅰ号方对大肠癌Mfolfox6方案化疗后腹泻的干预作用。方法:将126例大肠癌mfolfox6方案化疗后腹泻患者分为治疗组66例和对照组60例。治疗组采用痛泄Ⅰ号方治疗,对照组采用易蒙停治疗。两组均以7d为1个疗程,疗程结束后统计疗效。结果:总有效率治疗组为89.4%,对照组为71.7%,两组比较,差异有统计学意义(P<0.05);KPS评分改善率治疗组为62.1%,对照组为38.3%,两组比较,差异有统计学意义(P<0.05);两组中医证候积分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05,P<0.01)。结论:痛泄Ⅰ号方对大肠癌mfolfox6方案化疗后腹泻患者有较好的疗效。
Objective: To observe the effect of Tongxie I Prescription on diarrhea after Mfolfox6 regimen in patients with colorectal cancer. Methods: 126 patients with diarrhea after chemotherapy of mfolfox6 regimen were divided into treatment group (66 cases) and control group (60 cases). The treatment group was treated with Tongxi Ⅰ, while the control group was treated with Yi Mengtan. Both groups were 7d for a course of treatment, after the end of treatment statistics. Results: The total effective rate was 89.4% in the treatment group and 71.7% in the control group, with significant difference between the two groups (P <0.05). The improvement rate of KPS score was 62.1% in the treatment group and 38.3% in the control group, (P <0.05). There was significant difference between the two groups in TCM syndrome score before and after treatment and after treatment, the difference was statistically significant (P <0.05, P <0.01). Conclusion: Tongxi Ⅰ decoction has good curative effect on patients with diarrhea after mfolfox6 regimen of colorectal cancer.