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目的:研究安宫牛黄丸联合经颅低频磁刺激对帕金森病(PD)患者运动和情感障碍的改善作用。方法:选取2010年4月—2015年3月期间医院收治的100例PD患者作为研究对象,将患者随进分为两组:观察组50例,接受安宫牛黄丸联合经颅低频磁刺激治疗(TMS);对照组50例,接受经颅低频磁刺激治疗。比较两组患者的临床疗效、治疗前后的UPDRS评分、HAMD和HAMA评分。结果:观察组患者的有效率为92.00%,对照组为78.00%,差异具有统计学意义(P<0.05)。两组患者治疗后的UPDRS总分,UPDRS I、UPDRSII和UPDRSIII评分,HAMD和HAM评分的差异具有统计学意义(P<0.05)。结论:安宫牛黄丸联合经颅低频磁刺激可以明显改善帕金森患者的运动和情感障碍。
Objective: To investigate the effect of Angong Niuhuang Wan combined with transcranial low frequency magnetic stimulation on motor and affective disorder in Parkinson disease (PD) patients. Methods: A total of 100 patients with PD who were admitted to our hospital from April 2010 to March 2015 were selected as study subjects. The patients were divided into two groups according to their progression: 50 cases in observation group and Angong Niuhuang Pill combined with transcranial low frequency magnetic stimulation (TMS); control group, 50 patients underwent transcranial low-frequency magnetic stimulation. The clinical efficacy, UPDRS scores, HAMD and HAMA scores before and after treatment were compared between the two groups. Results: The effective rate of the observation group was 92.00% and that of the control group was 78.00%, the difference was statistically significant (P <0.05). UPDRS score, UPDRS I, UPDRSII and UPDRSIII score, HAMD and HAM score after treatment in both groups were statistically significant (P <0.05). Conclusion: Angong Niuhuang Pills combined with transcranial low frequency magnetic stimulation can significantly improve Parkinson ’s motor and affective disorder.