论文部分内容阅读
合成了4-脱氧-4-磺酰胺基-4′-去甲表鬼臼毒素衍生物25个。在抑制 L1210白血病细胞和 KB 细胞的试验中,大部分磺酰胺基表鬼臼毒素显示比依托泊甙更强的活性。简要讨论了该类化合物的结构-活性关系。
Twenty-five 4-deoxy-4-sulfonamido-4’-demethylepipodophyllotoxin derivatives were synthesized. In tests of inhibiting L1210 leukemia cells and KB cells, most of the sulfonamide-based epipodophyllotoxins showed more potent activity than etoposide. The structure-activity relationship of these compounds is briefly discussed.