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目的探讨心肌肌钙蛋白I(CTnI)、肌红蛋白(Mb)联合检测在急性心肌梗死(AMI)早期诊断中的的应用价值。方法采集56例AMI患者于胸痛发作0~4 h、8 h、12 h、24 h、48 h、3 d、5 d和7 d的血清,以及对照组48例的空腹血清同步进行cTnI与Mb的动态检测。结果AMI组血清cTnI、Mb的浓度均高于对照组(P<0.01)。AMI患者的早期0~4 h Mb的灵敏度明显高于cTnI;而8 h以后cTnI的灵敏度和准确度明显高于Mb。结论CTnI、Mb作为心肌损伤的早期标志物联合检测,可提高急性心肌梗死早期诊断的特异性和敏感性。
Objective To investigate the value of combined detection of cardiac troponin I and Mb in the early diagnosis of acute myocardial infarction (AMI). Methods Fifty-six patients with acute myocardial infarction (AMI) were enrolled in this study. Serum samples of chest pain patients were collected at 0-4 h, 8 h, 12 h, 24 h, 48 h, 3 d, 5 d and 7 d after chest pain attack. Dynamic detection. Results The serum levels of cTnI and Mb in AMI group were higher than those in control group (P <0.01). The sensitivity of Mb from 0 to 4 h in AMI patients was significantly higher than that of cTnI, and the sensitivity and accuracy of cTnI after 8 h was significantly higher than that of Mb. Conclusion The combined detection of CTnI and Mb as early markers of myocardial injury can improve the specificity and sensitivity of early diagnosis of acute myocardial infarction.