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1929年,Macheboeuf首先从马血清中分离出一种含有脂类和蛋白质的物质,命名为“酸沉淀性Coenapse。其后,这种物质被称为脂蛋白。但直到1948年,脂蛋白的分类未超出α与β两类。进入50年代后,将超速离心法和电泳法用于脂蛋白的分离获得成功,脂蛋白被分为CM(原点)、VLDL(前β脂蛋白)、LDL(β脂蛋白)及HDL(α脂蛋白)等四类。尤其在发现冠心病(CHD)人血浆LDL升高、HDL降低后,血浆脂蛋白的研究引起人们极大的关注和兴趣。开始,人们的注意力集中在LDL与CHD的关系,对
Macheboeuf first isolated a lipid and protein-containing substance from horse serum in 1929 and named it “Acid Precipitated Coenapse.” Later on, the substance was called lipoprotein, but until 1948 the classification of lipoproteins Did not exceed the two types of α and β into the 1950s, ultracentrifugation and electrophoresis for the successful separation of lipoproteins, lipoproteins were divided into CM (origin), VLDL (pre-beta lipoprotein), LDL Lipoprotein) and HDL (alpha lipoprotein), etc. In particular, the study of plasma lipoprotein has drawn great attention and interest especially in the discovery of elevated plasma LDL and decreased HDL in patients with coronary heart disease (CHD) Attention is focused on the relationship between LDL and CHD, right