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目的 通过检测食管癌组织中myc族癌基因的扩增情况探讨myc族癌基因与食管癌发生、发展及预后的关系。方法 聚合酶链反应 (PCR)测定。结果 myc族癌基因的阳性扩增率 5 5 .0 % (11/2 0 )。其过表达与肿瘤分化程度、浸润范围、淋巴结转移、临床病理分期方面在统计学上有差异 (P <0 .0 5 ) ,而与病人年龄、肿瘤部位在统计学上无差异性 (P >0 .0 5 )。结论 myc族癌基因的过表达与食管癌的生物学行为有关。有可能为食管癌病人的防治及预后判定提供新的方法。
Objective To investigate the relationship between the myc family oncogenes and the occurrence, development and prognosis of esophageal cancer by detecting the amplification of myc family oncogenes in esophageal cancer tissues. Methods Polymerase chain reaction (PCR) assay. Results The positive rate of myc gene oncogene amplification was 55.0% (11/2). There was a statistically significant difference between the overexpression and the degree of tumor differentiation, extent of invasion, lymph node metastasis and clinicopathological stage (P <0.05), but not with age and tumor location (P> 0 .0 5). Conclusion The overexpression of oncogene in myc is associated with the biological behavior of esophageal cancer. It is possible for the prevention and treatment of esophageal cancer patients and prognosis to provide a new method.