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本文采用静脉注射小牛结晶性血清白蛋白(由小剂量逐渐增大),用弗氏佐剂作辅助免疫,诱发家兔慢性肾小球肾炎,结果免疫荧光显示肾小球系膜区及毛细血管丛基底膜逐渐出现强度不等的IgG颗粒状沉积;光镜下,系膜细胞呈进行增生伴有系膜基质增多和局限性肾小球硬化;电镜下见肾小球毛细血管丛系膜区及基底膜上皮侧和内皮下电子致密物沉积。上述病变类似人类系膜增生性肾炎,进一步说明循环免疫复合物沉着可引起多种类型慢性肾炎。
In this article, intravenous injection of calf serum albumin (a gradual increase from a small dose), adjuvanted with Freund’s adjuvant to induce rabbit chronic glomerulonephritis, the results of immunofluorescence showed glomerular mesangial area and capillary The basal membrane of the vascular plexus gradually appeared IgG granular deposition with different intensity; Under light microscope, the mesangial cells showed hyperplasia with increased mesangial matrix and localized glomerular sclerosis; glomerular capillary plexus mesangium was seen under electron microscope. Area and basement membrane epithelial side and subendothelial electron dense deposits. The above lesions resemble human mesangial proliferative nephritis, further illustrating that circulating immune complexes can cause multiple types of chronic nephritis.