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目的分析东海县儿童肠道病毒CA16中和抗体水平及自然感染状况,为预防控制儿童手足口病的传播与流行及制定疫苗免疫程序提供依据。方法对东海县420名15岁以下儿童及20名新生儿的母亲,进行血清中CA16中和抗体测定。结果 420名儿童中,血清CA16中和抗体阳性125人,阳性率为29.76%,中和抗体几何平均滴度为1∶7.33,不同年龄组CA16中和抗体阳性率差异有统计学意义(χ2=96.620,P<0.05);中和抗体几何平均滴度,各年龄组间差异有统计学意义(F=4.909,P<0.05)。不同性别儿童CA16中和抗体阳性率和几何平均滴度差异无统计学意义(χ2=0.081,P>0.05;F=0.366,P>0.05)。结论东海县儿童CA16中和抗体水平与年龄关系密切,5岁以下儿童是CA16感染引起手足口病流行的主要易感人群,也是手足口病防控的重点人群。
Objective To analyze the neutralizing antibody level and natural infection status of CA16 of enterovirus in Donghai County and provide basis for prevention and control of the spread and epidemic of hand-foot-mouth disease in children and vaccine vaccination program. Methods 420 mothers of children under 15 and 20 newborns in Donghai County were tested for serum CA16 neutralizing antibody. Results Among 420 children, the positive rate of neutralizing antibody of CA16 was 125, the positive rate was 29.76%. The geometric mean titer of neutralizing antibody was 1: 7.33. The positive rate of CA16 neutralizing antibody in different age groups was significantly different (χ2 = 96.620, P <0.05). The geometric mean titers of neutralizing antibodies were significantly different among all age groups (F = 4.909, P <0.05). There was no significant difference in the positive rate and the geometric mean titer of neutralizing antibody of CA16 between children of different genders (χ2 = 0.081, P> 0.05; F = 0.366, P> 0.05). Conclusion The CA6 neutralizing antibody level in children of Donghai County is closely related to age. Children under 5 years of age are the predominant susceptible population of HFMD caused by CA16 infection, and are also the key population for prevention and control of HFMD.