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目的探讨叶酸受体介导的宫颈特殊染色法(FRD)在宫颈病变检查中的意义。方法选取2013年1-12月松江区妇幼保健院门诊和住院患者2 743例,分别进行FRD及液基薄层细胞学检查,以病理学诊断为金标准比较两种方法的优劣。结果以宫颈上皮内瘤变(CIN)Ⅱ~Ⅲ级为阳性标准,FRD的敏感性为80.60%,特异性为72.70%,阳性预测值为76.30%,阴性预测值为77.40%;液基薄层细胞学检查的敏感性为83.30%,特异性为42.40%,阳性预测值为61.20%,阴性预测值为70.00%。结论作为较准确、简便、快速、经济的检测手段,FRD对宫颈癌和癌前病变检查有重要的临床意义,是宫颈病变的重要临床评估标准。
Objective To investigate the significance of folic acid receptor-mediated cervical special staining (FRD) in cervical lesions. Methods A total of 2 743 outpatients and inpatients from MCH in Songjiang District from January to December in 2013 were selected for FRD and liquid-based thin-layer cytology. The pathological diagnosis was used as the gold standard to compare the advantages and disadvantages of the two methods. Results The positive rate of grade Ⅱ ~ Ⅲ of cervical intraepithelial neoplasia was 80.60%, specificity of 72.70%, positive predictive value of 76.30% and negative predictive value of 77.40% The sensitivity of cytology was 83.30%, the specificity was 42.40%, the positive predictive value was 61.20% and the negative predictive value was 70.00%. Conclusion As a more accurate, simple, rapid and economical means of detection, FRD has important clinical significance for the examination of cervical cancer and precancerous lesions and is an important clinical evaluation criterion for cervical lesions.