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目的前瞻性研究葡聚糖微球经双侧子宫动脉栓塞子宫肌瘤的临床疗效。方法将2003年1月至2010年12月收住的60例子宫肌瘤患者随机分为观察组和对照组,每组各30例。观察组30例患者用葡聚糖微球(Sephadex,G-50,100～300μm)行双侧子宫动脉栓塞术;对照组30例患者采用海藻酸钠微球(KMG,直径500～700μm)栓塞。观察两组患者在栓塞术前后月经量、子宫体积、肌瘤体积、性激素水平的变化以及住院费用的差异。结果两组插管栓塞成功率100%,术后平均随访6个月,两组患者月经量减少,子宫及肌瘤体积明显缩小,性激素无明显变化。上述各参数两组比较差异无统计学意义(均P>0.05)。葡聚糖微球栓塞组费用降低,两组间差异有统计学意义(P<0.05)。结论葡聚糖微球栓塞剂栓塞治疗子宫肌瘤是有效和安全的。而且价格低廉,值得临床开发应用。
Objective To prospectively study the clinical efficacy of dextran microspheres embolization of uterine fibroids by bilateral uterine artery. Methods Sixty patients with uterine fibroids admitted from January 2003 to December 2010 were randomly divided into observation group and control group, with 30 cases in each group. Thirty patients in the observation group underwent bilateral uterine arterial embolization with dextran microspheres (G-50, 100-300 μm). Thirty patients in the control group were embolized with sodium alginate microspheres (KMG, 500-700 μm in diameter). The changes of menstrual flow, uterine volume, myoma volume, sex hormone levels and hospitalization costs before and after embolization were observed in two groups of patients. Results The success rate of intubation embolization was 100% in both groups. The average follow-up time was 6 months. The menstrual volume was reduced in both groups, the volume of uterus and fibroids was significantly reduced, but there was no significant change in sex hormones. The above parameters were no significant difference between the two groups (all P> 0.05). Dextran microspheres embolization group costs reduced, the difference between the two groups was statistically significant (P <0.05). Conclusion Dextran microspheres embolization embolization for the treatment of uterine fibroids is effective and safe. And low prices, it is worth clinical development and application.