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本文应用ＮＳＥＥ诱发ＮＩＨ小鼠前胃鳞癌的动物模型，观察了复合核黄素和纯核黄素对小鼠前胃鳞状上皮癌变的影响。结果表明，复合核黄素对ＮＳＥＥ诱发小鼠前胃鳞癌有明显抑制作用，其抑制率为５４．８４％（Ｐ＜０．０５）。而纯核黄素未发现明显的阻断癌变的作用。提示，其有效成分可能不是核黄素，而是核黄素以外的其它成分或是核黄素与其它成分的协同作用。本研究为食管癌的预防研究提供了实验依据。
In this study, we used NSEE to induce the animal model of precancerous squamous cell carcinoma in NIH mice and observed the effects of combined riboflavin and pure riboflavin on the carcinogenesis of mouse squamous epithelium. The results showed that compound riboflavin had significant inhibitory effect on NSEE-induced precancerous squamous cell carcinoma in mice, and the inhibition rate was 54.84% (P<0.05). Pure riboflavin did not show any significant blockade of cancer. It is suggested that the active ingredient may not be riboflavin but other components than riboflavin or synergistic effects of riboflavin and other components. This study provides experimental evidence for the prevention of esophageal cancer.