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采用体外细胞培养技术,观察兔肺泡巨噬细胞死亡率,用丙二醛(MDA)的含量变化,乳酸脱氢酶(LDH)及超氧化物歧化酶(SOD)的活性变化来评价来自12个矿床的6种矿物的12种结晶习性的矿物粉尘的细胞毒性,探讨其使巨噬细胞受损的机制。结果表明,沸石、硅灰石无细胞毒性,而其他的纤维状及
The death rate of alveolar macrophages in rabbits was observed by cell culture in vitro. The changes of malondialdehyde (MDA) content, activity of lactate dehydrogenase (LDH) and superoxide dismutase (SOD) The cytotoxicity of 12 kinds of crystal habit minerals dust of 6 kinds of minerals in ore deposit and the mechanism of macrophage damage were discussed. The results show that zeolite, wollastonite without cytotoxicity, while other fibrous and