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目的 探讨十二指肠溃疡患者幽门螺杆菌 (Hp)感染与胃窦粘膜炎症反应和炎症介质含量的关系。 方法 取70例十二指肠溃疡患者胃窦粘膜组织作炎症活动性和炎症程度分级、Hp W -S染色和炎症介质含量测定。结果 十二指肠溃疡患者胃窦粘膜炎症反应Hp阳性者比阴性者严重 ;且十二指肠溃疡患者胃窦粘膜炎症活动性和炎症程度分级与Hp感染分级呈正相关。Hp阳性者胃窦粘膜内炎症介质含量比Hp阴性者高 ,且炎症介质含量随着Hp感染程度和胃窦炎症反应的加重而升高。结论 炎症介质在Hp相关性胃窦炎和十二指肠溃疡的发生中起重要的纽带作用
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and inflammation of antral mucosa and inflammatory mediators in patients with duodenal ulcer. Methods The antral mucosa of 70 patients with duodenal ulcer were divided into three groups according to the degree of inflammatory activity and inflammation, Hp W-S staining and inflammatory mediators. Results Duodenal ulcer patients with antral gastric mucosal inflammation Hp positive than the negative were serious; and duodenal ulcer patients with antral gastric mucosal inflammatory activity and grade of inflammation was positively correlated with the classification of Hp infection. Hp-positive gastric mucosa in antral inflammatory mediators than Hp-negative, and inflammatory mediators increased with the degree of Hp infection and antral inflammatory response increased. Conclusions Inflammatory mediators play an important role in the formation of Hp-associated gastric antrum and duodenal ulcer