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目的观察和比较抗病毒治疗联合美沙酮治疗HIV感染的临床效果。方法选择医院2011-2013年HIV感染患者100例,其中A组36例仅采用美沙酮治疗,B组33例仅采用抗病毒治疗,C组31例采用抗病毒联合美沙酮治疗,对比和分析3组患者的HIV病毒载量、CD4+、血常规及肝肾功能的情况。结果治疗后,C组的HIV病毒载量显著低于A、B组,差异有统计学意义(P<0.05)。C组CD4+水平、血常规及肝肾功能改善情况显著显著优于A、B组,差异有统计学意义(P<0.05)。结论联合使用抗病毒和美沙酮治疗HIV感染可以有效降低患者的HIV病毒载量,改善患者的病情,具有重要的临床应用价值。
Objective To observe and compare the clinical effects of antiviral therapy combined with methadone in the treatment of HIV infection. Methods 100 cases of HIV-infected patients in the hospital from 2011 to 2013 were selected. Among them, 36 cases in group A were treated with methadone alone, 33 cases in group B were treated with antiviral therapy only, 31 cases in group C were treated with antiviral combined with methadone. Of HIV viral load, CD4 +, blood and liver and kidney function. Results After treatment, the HIV viral load of group C was significantly lower than that of group A and B (P <0.05). The improvement of CD4 + level, blood routine and liver and kidney function in group C was significantly better than that in group A and B (P <0.05). Conclusion Combined use of anti-virus and methadone in the treatment of HIV infection can effectively reduce HIV viral load and improve the patient’s condition, which has important clinical value.