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目的：分析乳腺神经内分泌癌的临床病理学特征及预后因素。方法收集43例乳腺神经内分泌癌的临床资料和生存情况，分析其临床病理特点和预后因素。结果所有患者中位随访时间48个月（8～90个月），患者5年总生存率为67％。单因素分析显示腋窝淋巴结转移（P＝0．037）、较晚的TNM分期（P＝0．005）、较高的组织学分级（P＝0．005）和Ki-67高表达（P＝0．040）与患者生存差相关，多因素分析显示仅组织学分级（P ＝0．022）是患者预后的独立因素。结论乳腺神经内分泌癌是一类具有特殊临床病理特征的乳腺癌，常用的临床病理学指标中仅组织学分级是其独立预后因素。“,”Objective To investigate the clinicopathologic features and prognostic factors of pri-mary neuroendocrine cancer of the breast(NECB).Method The clinical data and survival status of 43 cases of NECB were collected to analyze clinicopathologic characteristics and prognostic factors.Result The median follow-up for all patients with NECB was 48 months(range,8~90 months).The 5-year overall survival rate was 67%.Univariate analysis showed that the presence of regional lymph node metastasis(P=0.037),advanced TNMstage(P=0.005),advanced histological grade(P=0.005)and high level of Ki-67(P=0.040)were correlated with the poor overall survival.However,multivariate analysis showed that only histological grade(P=0.022)was the independent prognostic factor.Conclusion NECB is a subtype of mammary carcinoma with several distinctive clinicopathologic features.Among the common used clinicopathologic factors,histological grade is the only independent prognostic predictor of the survival of NECB.