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艾滋病病毒(HIV)通过外膜蛋白与CD4分子相互作用直接入侵宿主细胞,趋化因子受体在此过程中发挥重要辅助作用。明确HIV与趋化因子受体相互作用的分子机制,对于研发新型抗HIV药物具有重要意义。
HIV (human immunodeficiency virus) directly invades host cells through the interaction of outer membrane proteins with CD4 molecules, and chemokine receptors play an important supporting role in this process. To clarify the molecular mechanism of HIV-chemokine receptor interaction is of great significance for the development of new anti-HIV drugs.