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目的探讨缺血性脑血管病患者血清神经元特异性烯醇化酶(NSE)的表达及临床价值。方法采用电化学发光法,对40例急性脑梗死患者和30例短暂性脑缺血发作患者血清NSE含量进行检测,并检测30例健康正常人血清NSE含量为对照组,对结果进行对比分析。结果急性脑梗死组血清NSE浓度明显高于短暂性脑缺血发作组和对照组(P<0.05),短暂性脑缺血发作组血清NSE高于健康正常人血清NSE(P<0.05),组间差异有统计学意义。结论缺血性脑血管病患者血清NSE含量升高与脑神经细胞坏死密切相关,可以反映脑神经细胞缺血损伤程度;血清中NSE高表达有可能提示超早期脑梗死,而低表达可能是TIA,检测血清NSE可以在血清学上为鉴别超早期急性脑梗死及短暂性脑缺血发作提供一个有临床意义的指标,对指导临床用药有积极的意义。
Objective To investigate the expression and clinical value of serum neuron specific enolase (NSE) in patients with ischemic cerebrovascular disease. Methods Electrochemical chemiluminescence was used to detect the serum NSE levels in 40 patients with acute cerebral infarction and 30 patients with transient ischemic attack. The serum NSE levels were measured in 30 healthy controls as control group, and the results were compared. Results Serum NSE concentration in acute cerebral infarction group was significantly higher than that in transient ischemic attack group and control group (P <0.05). The serum NSE in transient ischemic attack group was higher than that in healthy normal human serum (P <0.05) Between the differences was statistically significant. Conclusion Serum NSE levels in patients with ischemic cerebrovascular disease are closely related to the neuronal cell necrosis, which can reflect the degree of ischemic injury of cerebral neurons. High expression of NSE in serum may indicate ultra-early cerebral infarction, while low expression may be TIA The detection of serum NSE can provide a clinically meaningful indicator for the identification of ultra-early acute cerebral infarction and transient ischemic attack in serology, which is of positive significance for guiding clinical medication.