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目的评价不同浓度平阳霉素局部注射治疗口腔颌面部淋巴管畸形的临床疗效。方法回顾分析2006年1月至2013月5月在中国医科大学附属口腔医院口腔颌面外科采用平阳霉素局部注射治疗的82例淋巴管畸形患者的临床资料。对不同类型、同一类型不同大小的淋巴管畸形采用不同浓度的平阳霉素治疗,具体如下:微囊型淋巴管畸形为8 mg/8 mL;病损直径<5 cm的大囊型及混合型淋巴管畸形为8 mg/5 mL;病损直径>5 cm的大囊型淋巴管畸形为8 mg/3 mL。随访时间为6个月至3年。结果微囊型淋巴管畸形治愈率为43.3%;病损直径<5 cm的大囊型淋巴管畸形治愈率为93.3%;病损直径>5 cm的大囊型淋巴管畸形治愈率为88.9%;混合型淋巴管畸形的治愈率为60.0%。所有患者术后均出现局部肿胀、疼痛,出现全身发热4例,出现局部溃疡1例,均未见肺纤维化及严重不良反应发生。结论对不同类型、同一类型不同大小的淋巴管畸形采用适宜浓度的平阳霉素进行治疗,不仅可以提高疗效、缩短疗程,而且可以减少不必要的并发症发生,治疗相对安全。
Objective To evaluate the clinical effect of local injection of Pingyangmycin in the treatment of lymphatic malformations in oral and maxillofacial regions. Methods The clinical data of 82 patients with lymphatic vessel malformation treated by Pingyangmycin injection in oral and maxillofacial surgery at the Stomatological Hospital of China Medical University from January 2006 to May 2013 were retrospectively analyzed. Different types of the same type of lymphatic malformations of different sizes with different concentrations of pingyangmycin treatment, as follows: microcapsule lymphatic malformation 8 mg / 8 mL; lesion diameter <5 cm of the large capsule and mixed type The lymphatic vessel deformity was 8 mg / 5 mL. The large cystic lymphangitic malformation with lesion diameter> 5 cm was 8 mg / 3 mL. Follow-up time was 6 months to 3 years. Results The cure rate of microcapsullary lymphatic malformation was 43.3%. The cure rate of large cystic lymphangitic deformity with diameter less than 5 cm was 93.3%. The cure rate of large cystic lymphatics malformation with lesion diameter> 5 cm was 88.9% The cure rate of mixed lymphatic malformation was 60.0%. All patients showed local swelling and pain after operation, with 4 cases of systemic fever and 1 case of local ulcer. No pulmonary fibrosis and serious adverse reactions occurred. Conclusion Different types of lymphatic malformations of the same type and different sizes can be treated with the appropriate concentration of pingyangmycin, which can not only improve curative effect and shorten the course of treatment, but also reduce the unnecessary complications and the treatment is relatively safe.