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Damyanov等根据Shafik采用经直肠途径给药治疗盆腔恶性肿瘤的经验,进行动物实验。结果显示在膀胱壁的药物脓度较血浆中高5倍,付作用轻微。1988.12～1990.11作者采用经肛门粘膜下注射MXT氨甲喋呤)治疗晚期膀胱癌(T_2-T_4)20例,报导了初步结果。病人和方法;20例病人,男18,女2,平均59.5岁;肿瘤分期T_2、6例,T_3、11例,T_4、3例。截石位,50mg MXT稀积于10ml生理盐水中,用17～18cm长针,经肛门超过齿状线于直肠前壁作粘膜下注射,退回针头时,可见粘膜呈丘状隆起。
Based on Shafik’s experience with transrectal drug delivery of pelvic malignancies, Damyanov et al. Conducted animal experiments. The results showed that the drug in the bladder wall purulence five times higher than plasma, pay a minor role. 1988.12 ~ 1990.11 The authors used transmucosal injection MXT methotrexate) treatment of advanced bladder cancer (T_2-T_4) in 20 cases, the preliminary results were reported. Patients and methods; 20 patients, male 18, female 2, average 59.5 years; tumor staging T_2,6 cases, T_3,11 cases, T_4,3 cases. Lithotomy position, 50mg MXT dilute in 10ml saline, with 17 ~ 18cm long needle, the anus over the dentate line in the rectal wall for submucosal injection, returned to the needle, the mucosa showed mound bulge.