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测定了18名健康人和26例流行性出血热(EHF)患者的肾小球滤过率(GFR)及有效肾血浆流量(ERPF)。健康人GFR 为104.2±21.9ml/min,ERPF 为580±77ml/min,EHF 患者从发热期至多尿期GFR 与ERPF 均显著下降(P<0.05～0.01),重型病例较中型更明显。同时检测了血浆血管紧张素-Ⅱ(AT-Ⅱ)、血栓素B_2(TXB_2)和6-酮-前列腺素F_(1α)(6-K-PGF_(1α)),结果显示病程前三期血浆AT-Ⅱ和TXB_2明显高于正常,TXB_2/6-K-PGF_(1α)比值显著上升。作者认为有效血容量减低以及血管活性物质的变化是引起GFR 与ERPF 下降的重要因素。
Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured in 18 healthy individuals and 26 patients with epidemic hemorrhagic fever (EHF). The GFR of healthy people was 104.2 ± 21.9ml / min and the ERPF was 580 ± 77ml / min. The GFR and ERPF of EHF patients were significantly decreased from fever period to polyuria (P <0.05 ~ 0.01). Plasma levels of AT-Ⅱ, TXB_2 and 6-K-PGF_ (1α) were also measured. The results showed that plasma levels of plasma AT-Ⅱand TXB_2 were significantly higher than normal, and the ratio of TXB_2 / 6-K-PGF_ (1α) increased significantly. Authors believe that effective blood volume reduction and changes in vasoactive substances is an important factor in the decline caused by GFR and ERPF.