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目的分析2000—2010年我国化学物中毒性周围神经病的流行状况。方法 通过文献检索收集2000—2010年我国化学物中毒性周围神经病病例及中毒事件,对化学物中毒性周围神经病的原因、地区分布、毒物构成等进行分析。结果 2000—2010年我国文献报道化学物中毒性周围神经病2 329例,分布于全国19个省市。职业性中毒1 359例(58.4%),非职业性中毒953例(40.9%),不明原因中毒17例(0.7%)。职业性中毒性周围神经病中致病化学物以正己烷居首位(43.0%);非职业性中毒性周围神经病以有机磷杀虫剂中毒所致的迟发性周围神经病为多见(52.8%)。结论 化学物中毒性周围神经病在我国时有发生,应加强毒物危害宣传、职业卫生监督管理及劳动防护宣传教育,治理环境,及时治疗中毒病例,减少化学物中毒性周围神经病的发生。
Objective To analyze the prevalence of toxic peripheral neuropathy in China from 2000 to 2010. Methods The cases of poisoning peripheral neuropathy and poisoning events in China from 2000 to 2010 were collected through literature search. The causes, regional distribution and toxic components of toxic peripheral neuropathy were analyzed. Results From 2000 to 2010, 2 329 cases of toxic peripheral neuropathy were reported in our country, which were distributed in 19 provinces and cities in China. There were 1 359 cases (58.4%) of occupational poisonings, 953 cases (40.9%) of non-occupational poisonings and 17 cases (0.7%) of unknown causes of poisoning. The occupational toxic peripheral neuropathy pathogenic chemicals ranked first with n-hexane (43.0%); non-occupational toxic peripheral neuropathy with organophosphate insecticide poisoning caused by delayed peripheral neuropathy is more common (52.8% ). Conclusions The chemical toxic peripheral neuropathy occurs in our country from time to time. It is necessary to strengthen the publicity and education on poison hazard, occupational health supervision and management, labor protection, public health and environmental protection, and timely treat poisoning cases and reduce the occurrence of toxic peripheral neuropathy.