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目的:探讨早期肠内营养支持疗法在重症急性胰腺炎治疗中应用的有效性与安全性。方法:选择56例重症胰腺炎患者按营养支持不同将其随机分为对照组和观察组每组各28例,其中对照组给予常规治疗,观察组在对照组的基础上加用肠内营养支持治疗。分别观察比较两组患者血白细胞、血淀粉酶、尿淀粉酶水平,并发症发生率、感染率、病死率及住院时间。结果:观察组患者白细胞水平、血、尿淀粉酶明显降低;且平均住院时间较对照组短。此外,观察组的并发症发生率、病死率、住院时间均比对照组低,差异均有统计学意义(P<0.05)。结论:对于SAP的早期治疗,采用肠内营养支持疗法有助于改善患者的机体营养状况,因而可显著提高SAP的治愈率,降低并发症的发生率和病死率,并缩短住院时间。所以早期肠内营养疗法值得在临床广泛推广。
Objective: To investigate the effectiveness and safety of early enteral nutrition support in the treatment of severe acute pancreatitis. Methods: Fifty-six patients with severe acute pancreatitis were randomly divided into control group and observation group with 28 cases in each group according to nutritional support. The control group was given conventional treatment. The observation group was given enteral nutrition support on the basis of the control group treatment. The levels of leukocyte, blood amylase, urinary amylase, complication rate, infection rate, mortality and hospital stay were observed and compared between the two groups. Results: The levels of white blood cells, blood and urine amylase in observation group were significantly lower than those in control group. In addition, the incidence of complications, mortality and hospital stay in the observation group were lower than those in the control group, with significant differences (P <0.05). Conclusion: For the early treatment of SAP, enteral nutrition support therapy can improve the nutritional status of patients, which can significantly improve the cure rate of SAP, reduce the incidence of complications and mortality, and shorten the hospital stay. Therefore, early enteral nutrition therapy is widely recommended in the clinic.