论文部分内容阅读
本研究选取2015年1月至2016年1月来我院就诊的183例急性缺血性脑卒中患者(脑卒中组)与同期就诊非脑卒中患者183例(对照组),分别进行DE4D基因多态性检测。对比两组中的SNP83发现脑卒中组基因型CC与CT分别高达77.05%、20.77%,而且C等位基因为87.43,均明显高于对照组;对比SNP87发现,在各基因型与等位基因的比较中,脑卒中组与对照组无明显差异。脑卒中组,SNP83与SNP87的CT、CC、TT基因型占比在对阿司匹林敏感患者中与对阿司匹林抵抗的患者中无明显差异。DE4D基因SNP83与急性缺血性卒中有密切联系,其中C等位基因越高,发病风险越高,相对应SNP87则与该疾病发生相关性较小,这可为早期诊断及预防缺血性脑卒中提供强有力的理论依据。
In this study, 183 acute ischemic stroke patients (stroke group) and 183 non-stroke patients (control group) were enrolled in our hospital from January 2015 to January 2016. The patients with DE4D gene State detection. Comparing the two groups of SNP83 found that the genotype of stroke group CC and CT were 77.05%, 20.77%, respectively, and the C allele was 87.43, were significantly higher than the control group; compared SNP87 found that in each genotype and allele In the comparison, stroke group and control group no significant difference. In the stroke group, the proportions of CT, CC, TT genotypes of SNP83 and SNP87 were not significantly different among aspirin-susceptible patients and aspirin-resistant patients. DE4D gene SNP83 and acute ischemic stroke are closely linked, the higher the C allele, the higher the risk of the disease, the corresponding SNP87 with less correlation with the disease, which can be early diagnosis and prevention of ischemic brain Stroke provides a strong theoretical basis.