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目的探讨影响中晚期胸段食管鳞癌患者术后生存和预后的因素。方法采用COX比例风险模型回顾性分析新疆肿瘤医院行胸段食管癌根治术339例病例的临床资料。结果中晚期胸段食管鳞癌患者总1、3、5年生存率分别为80.49%、41.94%、23.12%,单因素分析显示体重减轻、血红蛋白水平、术前白蛋白水平、淋巴结转移个数、侵润深度、术后病理分期、脉管瘤栓与生存时间有关(P<0.05);多因素分析显示肿瘤侵润深度、淋巴结转移个数、术后病理分期、术前白蛋白水平是影响中晚期胸段食管鳞癌预后的独立因素。结论肿瘤侵润深度、淋巴结转移个数、术后病理分期、术前白蛋白水平是影响中晚期胸段食管鳞癌患者术后生存的独立因素。
Objective To investigate the factors that influence the postoperative survival and prognosis of patients with advanced thoracic esophageal squamous cell carcinoma. Methods The data of 339 cases of thoracic esophagectomy in Xinjiang Cancer Hospital were retrospectively analyzed with COX proportional hazards model. Results The overall 1, 3, 5-year survival rates of patients with advanced thoracic esophageal squamous cell carcinoma were 80.49%, 41.94% and 23.12% respectively. Univariate analysis showed that weight loss, hemoglobin, preoperative albumin, lymph node metastasis, The depth of invasion, the postoperative pathological staging, and the survival time of the tumor thrombus (P <0.05). Multivariate analysis showed that the depth of tumor invasion, the number of lymph node metastasis, postoperative pathological stage and preoperative albumin level were significant Independent Factors of Prognosis of Advanced Thoracic Esophageal Squamous Cell. Conclusions The depth of tumor invasion, the number of lymph node metastasis, postoperative pathological stage and preoperative albumin level are the independent factors influencing the postoperative survival of patients with advanced thoracic esophageal squamous cell carcinoma.