论文部分内容阅读
目的探讨不同分期食管癌的影像学及肿瘤分子标志物垂体肿瘤转化基因(PTTG)和基质金属蛋白酶(MMPs)进展。方法选择荆门市第一人民医院胸心外科2012年5月至2013年5月食管癌患者80例作为观察对象,均进行超声内镜(EUS)和CT检查,进行临床TNM分期,并与病理结果进行比较,评价不同检测方法的准确性,同时对癌组织中PTTG和MMP-9的蛋白表达进行检测,结合EUS检查临床分期进行分析,评价临床分期准确性。结果 EUS检查食管癌T分期准确率77.5%(62/80)显著高于CT检查55.0%(44/80),差异有统计学意义(χ2=9.06,P<0.05),检查N分期准确率75.0%(60/80)略低于CT检查77.5%(62/80),但差异无统计学意义(χ2=0.14,P>0.05);PTTG和MMP-9蛋白阳性表达率分别为68.8%(55/80)和62.5%(50/80);EUS与PTTG、MMP-9单独或联合检查可以提高食管癌T分期、N分期的准确率,但差异无统计学意义(P>0.05)。结论 EUS检查对食管癌患者T分期的诊断准确率较高,结合PTTG和MMP-9蛋白表达,提高诊断准确率。
Objective To investigate the imaging and tumor molecular markers of different stages of esophageal cancer, pituitary tumor transforming gene (PTTG) and matrix metalloproteinases (MMPs) progress. Methods Eighty patients with esophageal cancer from May 2012 to May 2013 in Jingmen First People’s Hospital were enrolled in this study. Both endoscopic ultrasonography (EUS) and computed tomography (CT) were performed. TNM staging was performed and compared with pathological findings The accuracy of different detection methods was evaluated. Meanwhile, the protein expression of PTTG and MMP-9 in cancer tissue was detected. Combined with the clinical staging of EUS examination, the clinical staging accuracy was evaluated. Results The accuracy of EUS in detecting staging of esophageal T was 77.5% (62/80), significantly higher than that of CT (55.0%, 44/80) (χ2 = 9.06, P <0.05). The accuracy of N staging was 75.0 The positive rates of PTTG and MMP-9 were 68.8% (55/68), respectively (P <0.05). The positive rates of PTTG and MMP- / 80) and 62.5% (50/80), respectively. EUS, PTTG and MMP-9 alone or in combination could improve the accuracy of T staging and N staging of esophageal cancer, but the difference was not statistically significant (P> 0.05). Conclusion EUS examination of esophageal cancer patients with high accuracy of T staging, combined with PTTG and MMP-9 protein expression, to improve the diagnostic accuracy.