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目的:探讨可溶性血管细胞粘附分子1(soluble vascular cell adhesion molecule-l,sVCAM-1)在妊娠肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)发病中的作用。方法:酶联免疫吸附法(ELISA)测定49例孕妇血清中sVCAM-1水平。结果:重型ICP组血清中sVCAM-1水平显著高于正常妊娠组(P<0.01),ICP组随着病情的加重该指标升高,差异有统计学意义(P<0.01);产后该项指标下降与正常妊娠组无显著性差异(P>0.05);sVCAM-1的升高与胆汁酸(TBA)、血清丙氨酸氨基转移酶(ALT)、血清天冬氨酸氨基转移酶(AST)呈正相关(P<0.01,P<0.05)。结论:粘附分子的异常表达可能是ICP发病机制的一个重要环节。
Objective: To investigate the role of soluble vascular cell adhesion molecule-1 (sVCAM-1) in the pathogenesis of Intrahepatic cholestasis of pregnancy (ICP). Methods: Serum levels of sVCAM-1 in 49 pregnant women were determined by enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of sVCAM-1 in severe ICP group were significantly higher than those in normal pregnancy group (P <0.01). The ICP group increased with the severity of illness, the difference was statistically significant (P <0.01) (P> 0.05). The increase of sVCAM-1 was positively correlated with the levels of bile acid (TBA), serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST) (P <0.01, P <0.05). Conclusion: Abnormal expression of adhesion molecules may be an important part of ICP pathogenesis.