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持久性有机污染物(persistent organic polutants,简称POPs)大多具有毒性,有的甚至致癌,但目前对POPs引起的健康风险仍知之甚少。本研究的假设是在含POPs场地邮政区居住妇女的乳腺癌风险增大。从纽约州计划与研究合作系统(SPARCS)等数据库中收集乳腺癌患者的信息及居住地危险废弃物暴露、经济收入和城市化等数据。以邮政区编码表征居住地,采用负二项回归方法,对纽约州30岁以上妇女乳腺癌医院出院率进行了模型分析,参数包括种族、年龄、污染暴露、经济收入和城市化率。结果显示,不同参数之间(如暴露与种族、暴露与收入、暴露与城市化)存在交互作用。对部分子群而言,与居住在不含危险废弃物场地邮政区的妇女相比,居住在含POPs场地邮政区的妇女乳腺癌出院率显著升高(率比(rate ratio,RR)1.10~1.34,P<0.05)。这种关系在非裔妇女中强于白种妇女、在城市化高的地区强于农村地区。调整了混杂因素后,某些妇女人群乳腺癌出院率升高与在含POPs场地邮政区居住有显著的关系。
Persistent organic polluters (POPs) are mostly toxic and even carcinogenic, but the current health risks to POPs are still poorly understood. The hypothesis of this study is that there is an increased risk of breast cancer among women living in postal areas with POPs venues. Collect information on patients with breast cancer and data on hazardous waste exposures, economic income and urbanization from a database such as the New York State Department of Planning and Research Cooperation (SPARCS). The postal code was used to characterize the place of residence. Negative binomial regression method was used to analyze the discharge rate of New York State women’s breast cancer hospital over the age of 30. The parameters included race, age, pollution exposure, economic income and urbanization rate. The results show that there are interactions between different parameters such as exposure and race, exposure and income, exposure and urbanization. For some subgroups, the rate of breast cancer hospital discharges among women living in postal areas with POPs venues was significantly higher than those living in postal areas without hazardous waste sites (rate ratio (RR) 1.10 ~ 1.34, P <0.05). This relationship is stronger among African-American women than white women and is stronger in urban areas than in rural areas. After adjusting for confounding factors, the increase in breast cancer hospital discharges in some women groups was significantly associated with living in postal areas containing POPs venues.