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Aim:To investigate the protective effect of diallyl sulfide(DAS),a constituent of garlic,against testosterone-inducedoxidative stress in male Swiss albino mice.Methods:The animals were given low(250 mg/animal)and high dose(500 mg/animal)of DAS in corn oil for 7 days along with testosterone(5 mg/kg body weight,i.p.).At the end of thestudy period,the prostate and the liver were dissected to determine various antioxidant enzyme levels(catalase,superoxide dismutase,glutathione reductase,glutathione-s-transferase)and lipid peroxidation.Results:In testoster-one treated mice,depleted antioxidant enzyme level was accompanied with enhancement in lipid peroxidation inprostate and liver.DAS significantly restored the testosterone-induced antioxidant enzymes and lipid peroxidation inthe both organs.These changes appear to be mediated by the antioxidant-enhancing effects of DAS.Conclusion:The results of the present study suggest that DAS is effective in exerting antioxidant effects by inhibiting testosterone-induced oxidative stress and might be helpful in preventing prostate cancer.(Asian J Androl 2006 Nov;8:719-723)
Aim: To investigate the protective effect of diallyl sulfide (DAS), a constituent of garlic, against testosterone-inducedoxidative stress in male Swiss albino mice. Methods: The animals were given low (250 mg / animal) and high dose (500 mg / animal) of DAS in corn oil for 7 days along with testosterone (5 mg / kg body weight, ip). At the end of the study period, the prostate and the liver were dissected to determine various antioxidant enzyme levels (catalase, superoxide dismutase, glutathione reductase, glutathione-s-transferase) and lipid peroxidation. Results: In testoster-one treated mice, depleted antioxidant enzyme level was accompanied with enhancement in lipid peroxidation in prostate and liver. DAS significantly restored the testosterone-induced antioxidant enzymes and lipid peroxidation inthe both organs. These changes appear to be mediated by the antioxidant-enhancing effects of DAS. Conlusion: The results of the present study suggest that DAS is effective in exerting antioxidant effects by inhibiting te stosterone-induced oxidative stress and might be helpful in preventing prostate cancer. (Asian J Androl 2006 Nov; 8: 719-723)