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探讨Ｃ－ｅｒｂＢ－２癌基因蛋白与类固醉激素受体联合检测在乳腺癌预后判断中的价值及两者的关系。方法用免疫组化技术对５７例乳腺良恶性肿瘤进行了Ｃ－ｅｒｂＢ－２癌基因蛋白、类固醇激素受体（ＥＲ、ＰＲ、ＡＲ）６５检测。结果５０例乳腺癌中２１例（４２％）Ｃ－ｅｒｂＢ－２过度表达，均为浸润性导管癌。７例良性病变均为阴性，ＥＲ，ＰＲ，ＡＲ阳性率分别为７２％，６２％，６６％。良性病变中２例ＥＲ，１例ＰＲ为弱阳性，余者为阴性，结论Ｃ－ｅｒｂＢ－２的表达与ＥＲ，ＰＲ，ＡＲ呈负相关关系〔Ｐ＜０．０５），在肿瘤细胞核级中，Ｃ－ｅｒｂＢ－２的表达与ＥＲ，ＰＲ崳粒乙渤矢合喙毓叵担ǎ颍剑埃梗常福常埃梗福担叮埃梗梗福担校迹埃埃担茫澹颍猓拢补缺泶镎吡馨徒嶙坡矢撸ǎ校迹眨眨保
To explore the value of combined detection of C-erbB-2 oncogene protein and glucocorticoid receptor in the prognosis of breast cancer and the relationship between them. Methods Immunohistochemical technique was used to detect C-erbB-2 oncogene protein and steroid receptor (ER, PR, AR) 65 in 57 cases of breast benign and malignant tumors. Results Overexpression of C-erbB-2 was found in 21 cases (42%) of 50 cases of breast cancer, which were all invasive ductal carcinomas. Seven cases of benign lesions were negative, and the positive rates of ER, PR and AR were 72%, 62%, and 66%, respectively. Among the benign lesions, 2 were ER, 1 was weakly positive, and the rest were negative. Conclusion The expression of C-erbB-2 is negatively correlated with ER, PR and AR (P<0.05). Expression of C-erbB-2 and ER, PR 崳 渤 渤 渤 渤 喙毓叵 ǎ颍 ǎ颍 ǎ颍 常 常 叮 叮 Traces 茫澹颍猓 茫澹颍猓 茫澹颍猓 泶镎 泶镎 泶镎 嶙 嶙 嶙 嶙 嶙 嶙