论文部分内容阅读
为了观察肿瘤病人的细胞免疫功能，应用单克隆抗体检测３０例不同组织学分型肺癌病人血中Ｔ淋巴细胞亚群。结果显示：腺癌与鳞癌主要表现为ＣＤ４＋细胞减少，大、小细胞癌是ＣＤ４＋细胞和ＣＤ８＋细胞均异常，其主要反映在ＣＤ４＋／ＣＤ８＋比值降低，提示不同组织学分型的肺癌患者Ｔ淋巴细胞亚群变化方式不同。ＣＤ４＋／ＣＤ８＋比值以大、小细胞癌下降最多，鳞癌其次，腺癌最少，提示肺癌患者免疫功能受抑制程度与组织类型有关。认为测定肺癌病人Ｔ淋巴细胞亚群，对分析肿瘤发展、判断其预后和疗效具有参考价值。
In order to observe the cellular immune function of tumor patients, monoclonal antibodies were used to detect the T lymphocyte subsets in blood of 30 patients with different histological subtypes of lung cancer. The results showed that the main manifestations of adenocarcinoma and squamous cell carcinoma were the reduction of CD4+ cells, and the abnormalities of CD4+ and CD8+ cells in large and small cell carcinomas were mainly reflected in the decreased ratio of CD4+/CD8+, suggesting different histological types of T lymphocytes in lung cancer patients. Subgroups change in different ways. The ratio of CD4+/CD8+ decreased most in large and small cell carcinomas, followed by squamous cell carcinoma and least in adenocarcinoma, suggesting that the degree of inhibition of immune function in lung cancer patients is related to the tissue type. It is considered that the determination of T-lymphocyte subsets in lung cancer patients has a reference value for the analysis of tumor development, judgment of its prognosis and efficacy.