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去甲斑蟊素是由北京第四制药厂人工合成的新抗肿瘤药,治疗肝癌有一定疗效,已于1984年11月在北京召开的鉴定会上通过鉴定,并开始正式投产。临床上早已使用斑蟊素治疗肝癌,并取得一定疗效,但由于斑蟊素对泌尿系有很强的刺激作用,严重的毒副反应,使得病人不能坚持治疗,影响疗效;再者,提取斑蟊素的资源有限,而合成又很困难,因此限制了斑蟊素在临床上的广泛使用。北京第四制药厂人工合成了斑蟊素的衍生物去甲斑蟊素。为了探讨斑蟊素去二甲基后对其活性的影响,北京第四制药厂在有关单位的协作下,就去甲斑蟊素的毒性、药理作用、作用机制等多方
Norcantharidin is a new anti-tumor drug synthesized by Beijing No. 4 Pharmaceutical Factory and has certain curative effect in the treatment of liver cancer. It has passed the appraisal at the appraisal meeting held in Beijing in November 1984 and formally put into operation. Clinidine has long been used in the treatment of liver cancer, and achieved a certain effect, but due to cantharidin on the urinary tract has a strong stimulating effect, serious side effects, making the patient can not adhere to the treatment, affecting the curative effect; Furthermore, Limulus pigment resources are limited, and the synthesis is very difficult, thus limiting the widespread use of cantharidin in the clinic. Beijing No. 4 Pharmaceutical Factory artificial synthesis of cantharidin derivatives norcantharidin. In order to explore the cantharidin to dimethyl activity after its impact, Beijing No. 4 Pharmaceutical Factory in collaboration with the relevant units on the norcantharidin toxicity, pharmacological effects, mechanism of action and many other