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绝大多数β-内酰胺抗生素排出,主要是通过肾小管分泌消除。文献曾报道青霉素、双氯青霉素、邻氯青霉素、哌拉西林、阿洛西林和美洛西林随血浓度增加而肾消除减少的现象。但是这些研究没有阐明肾小管的排泄过程。而且,近年来在一些抗生素的用量上远高于当时所介绍应用剂量。因此,搞清楚肾小管排泄过程中的饱和状况就显得更为重要了,除了临床上有重要意义外,对药物的生物利用度的阐明更有重要的实际意义。本文就此目的,对三个β-内酰胺抗生素的肾小管的排泄,以定量参数进行评价。作者对青霉素、邻氯青霉素和头孢拉定进行人体的实验研究,全部志愿者无肾、肝功
The vast majority of β-lactam antibiotics, mainly through the elimination of tubular secretion. It has been reported in the literature that penicillin, dicloxacillin, cloxacillin, piperacillin, azlocillin and mezlocillin decrease in renal elimination with increasing blood concentration. However, these studies did not elucidate the tubular excretion process. Moreover, the amount of some antibiotics used in recent years is much higher than the dose at the time of introduction. Therefore, it is even more important to find out the state of saturation in renal tubular excretion. In addition to the clinical significance, the elucidation of the bioavailability of drugs is of more practical significance. This article for this purpose, the three β-lactam antibiotic tubule excretion, quantitative parameters for evaluation. The author of penicillin, chloramphenicol and cephradine for human experimental study, all volunteers without kidney, liver function