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自本课题的最近一篇主要综述发表以来,人们对巨核细胞生成的知识已有了显著提高。本文主要考察了骨髓干细胞向血小板逐级分化的过程和涉及的调节活动。血小板是来自巨核细胞的无核血细胞。在发育、成熟期间,巨核细胞可生成除5-羟色胺(5-HT)以外的血小板全部成分。发育过程中巨核细胞形成各种多倍体。现已证明巨核细胞来源于未分化的祖细胞。这些前体细胞能在体外受刺激而成灶。虽然有人报道过这些细胞灶有二种或更多类型的细胞,如巨核细胞加粒细胞,红系细胞和(或)巨噬细胞,但通常巨核细胞灶发育仅限于单一的细胞系。
Since the publication of a major review of this topic, there has been a significant increase in the knowledge of megakaryocytopoiesis. This article examines the process by which bone marrow stem cells progressively differentiate into platelets and the regulatory activities involved. Platelets are non-nucleated blood cells from megakaryocytes. During development and maturation, megakaryocytes produce all platelet components other than serotonin (5-HT). The development of megakaryocytes in the formation of various polyploidy. It has been demonstrated that megakaryocytes are derived from undifferentiated progenitor cells. These precursor cells can be stimulated in vitro and formed. Although it has been reported that these cell foci have two or more types of cells, such as megakaryocytes plus granulocytes, erythroid cells, and (or) macrophages, megakaryocytic foci usually develop only in a single cell line.