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氯丙嗪常用作止吐药、镇静药和精神治疗药。氯两嗪主要的中毒反应即抑郁症、嗜睡、锥体外路系统症状、焦虑等均系该药累及中枢神经系统所致。氯雨嗪中毒的治疗包括支持治疗和胃排空后对症治疗。本文报告用纳洛酮(naloxone)成功地治疗了1例口服氯丙嗪引起严重神经系统功能低下的患儿。病例报告:4.5岁男孩,发病当天早晨一直正常。午后1点,发现其昏迷在床上。在急诊室,患儿处于深昏迷,对痛刺激无反应,瞳孔缩小(2mm),两侧相同,对光无反应。角膜反射存在,深腱反射对称,但减弱。直肠温度34.4℃,心率106次/分,呼吸20次/分,血压110/80mmHg,体检除头围47cm外均正常。胃内容物未见任何药片或其碎片。静注纳洛酮1.2mg后3～5分钟内苏醒,对触摸和痛刺激发生
Chlorpromazine commonly used as antiemetics, sedatives and psychotropic drugs. Chlorzoxazine main poisoning response that depression, lethargy, extrapyramidal system symptoms, anxiety, etc. are caused by the drug involving the central nervous system. Chlorpheniramine treatment includes symptomatic treatment after supportive therapy and gastric emptying. This article reports the successful treatment of 1 child with severe neurological dysfunction caused by oral chlorpromazine with naloxone. Case report: 4.5-year-old boy, normal morning of onset. 1 o’clock in the afternoon, found it unconscious in bed. In the emergency room, the child is in a deep coma and does not respond to painful stimuli. The pupil is constricted (2mm) and is the same on both sides and does not respond to light. Corneal reflex exists, the tendon reflex symmetry, but weakened. Rectal temperature 34.4 ℃, heart rate 106 beats / min, breathing 20 beats / min, blood pressure 110 / 80mmHg, physical examination except head circumference 47cm outside the normal. No stomach tablets or fragments of stomach contents. Intravenous Naloxone 1.2mg wake up within 3 to 5 minutes, the occurrence of touch and painful stimulation