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目的:探讨儿童肺炎衣原体感染与临床哮喘急性发作关系,为其临床诊治提供依据。方法:将我院收治的哮喘急性发作儿童260例作为观察组,选取同期无感染性疾病患儿200例作为对照组,比较两组患儿血清CP-IgM、CP-IgG、总IgE和nPCR等指标。结果:对照组患儿CPIgM、CP-IgG、nPCR的阳性率分别为9.5%、22.5%、6.5%,观察组患儿CP-IgM、CP-IgG、nPCR的阳性率分别为35.4%、52.7%、29.2%,两组之间各项指标差异具有极显著性意义(P<0.001);对照组患儿血清总IgE为427.5±239.7U/ml,观察组患儿血清总IgE为644.7±251.9U/ml,两组之间的差异具有显著性意义(t=1.932,P<0.05)。结论:肺炎衣原体感染是诱发儿童哮喘急性发作的重要因素,临床上应加强对肺炎衣原体感染的观察和检测,以有效的来防治儿童哮喘的急性发作。
Objective: To explore the relationship between Chlamydia pneumoniae infection and acute attack of asthma in children and provide evidence for its clinical diagnosis and treatment. Methods: Two hundred and sixty children with asthma exacerbation in our hospital were selected as the observation group, and 200 children without infection were selected as the control group. Serum CP-IgM, CP-IgG, total IgE and nPCR index. Results: The positive rate of CPIgM, CP-IgG and nPCR in the control group were 9.5%, 22.5% and 6.5% respectively. The positive rates of CP-IgM, CP-IgG and nPCR in the observation group were 35.4% and 52.7% , 29.2% respectively. There was significant difference between the two groups (P <0.001). The total serum IgE of the control group was 427.5 ± 239.7U / ml, and the total serum IgE of the observation group was 644.7 ± 251.9U / ml, the difference between the two groups was significant (t = 1.932, P <0.05). Conclusion: Chlamydia pneumoniae infection is an important factor inducing acute asthma in children. Clinically, the observation and detection of Chlamydia pneumoniae infection should be strengthened so as to effectively prevent and treat the acute attack of childhood asthma.