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目的观察实验兔发生重症减压病过程中凝血纤溶系统指标的变化,分析减压病加-减压过程对纤溶系统的影响。方法20只新西兰白兔,在0.7 MPa停留35 min,于4 min内匀速减压出舱。检测加压前、减压后兔血浆纤维蛋白原(FIB)、D-二聚体(D-Dimer)、凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)、纤溶酶-抗纤溶酶复合物(PAP)等指标。比较加压前和减压后实验动物以上指标变化的特点。结果经加-减压后血浆FIB含量由(2.97±0.20)g/L减少至(2.74±0.31)g/L,APTT值由加压前(58.24±3.22)s缩短至减压后(54.18±4.18)s,D-Dimer由(238.53±57.65)ng/ml下降至(198.46±75.31)ng/ml,PAP由(2.09±0.06)μg/ml下降至(1.45±0.14)μg/ml。结论快速匀速减压引起血浆PAP减少,提示,减压病时继发性纤溶功能受到抑制的原因可能是血浆纤溶酶的减少。
Objective To observe the changes of coagulation and fibrinolytic system during severe decompression sickness in experimental rabbits and analyze the effect of decompression sickness and decompression on fibrinolytic system. Methods Twenty New Zealand white rabbits were kept at 0.7 MPa for 35 min and decompressed at constant speed within 4 min. Before decompression, the levels of FIB, D-dimer, PT, APTT, plasminogen activator- Anti-fibrinolysis complex (PAP) and other indicators. The characteristics of the above indexes in experimental animals before and after decompression were compared. Results The plasma FIB level decreased from (2.97 ± 0.20) g / L to (2.74 ± 0.31) g / L after addition and depressurization, and APTT value decreased from 58.24 ± 3.22 s before decompression to 54.18 ± 4.18) s, D-Dimer decreased from (238.53 ± 57.65) ng / ml to (198.46 ± 75.31) ng / ml and PAP decreased from (2.09 ± 0.06) μg / ml to (1.45 ± 0.14) μg / ml. Conclusions The rapid and uniform decompression causes a decrease in plasma PAP, suggesting that the reason for the suppression of secondary fibrinolytic function during decompression sickness may be the decrease of plasma plasmin.