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本文应用同种(或异种)脱矿骨粉(DBP)移植并从临床、X 线及组织学上进行了新骨形成的研究。对29只大白鼠,46只家兔作了颅骨、腓骨缺损及腹壁的植入以及对19例牙周骨缺损,13例颌骨根端囊肿与13例拔牙窝的 DBP 植入,观察2～12个月。DBP 为经0.5NHCl 的脱矿骨。结果证实了0.5NHCl 脱矿骨作为移植材料具有骨形成的活性,能诱导新生骨。本文进一步从 DBP 中提取骨形态蛋白质(BMP)作了同样研究,也初步证实能刺激间质细胞诱导为骨形成细胞。
In this paper, the same (or different) demineralized bone powder (DBP) transplantation and clinical, X-ray and histological new bone formation. Thirty-nine rats and 46 rabbits were implanted with skull, fibula defect and abdominal wall, and 19 cases of periodontal bone defect, 13 cases of mandibular root cyst and 13 cases of extraction socket were treated with DBP. 12 months. DBP demineralized bone with 0.5NHCl. The results confirmed 0.5NHCl demineralized bone as a graft material with bone formation activity, can induce new bone. This article further extracted from bone morphogenetic protein (BMP) made the same study, but also initially confirmed to stimulate mesenchymal cells induced bone formation.