论文部分内容阅读
目的:探讨帕金森病患者血糖水平和帕金森病的关系。方法:290例帕金森病患者为观察组,选择年龄、性别、民族与帕金森病患者匹配的健康体检者290例为对照组。检测2组受检者血糖水平,并进行比较。结果:高血糖患者观察组58例,对照组32例,2组高血糖检出率差异有统计学意义(χ2=4.95,P<0.05)。观察组空腹血糖、餐后2 h血糖水平均高于对照组,但差异无统计学意义(P>0.05)。二分类非条件Logistic回归分析结果显示,吸烟可能与帕金森病存在一定负相关(P<0.05),文化程度、餐后2 h高血糖可能与帕金森病存在一定正相关(P<0.05)。结论:高血糖可能与帕金森病的发生存在一定关系,临床监测和控制空腹血糖、餐后2 h血糖可为帕金森病的防治提供实验室依据。
Objective: To investigate the relationship between blood glucose level and Parkinson’s disease in Parkinson’s disease patients. Methods: A total of 290 patients with Parkinson’s disease were selected as observation group. 290 healthy subjects who were matched for age, sex, ethnicity and Parkinson’s disease were selected as the control group. Blood sugar levels of two groups were tested and compared. Results: There were 58 cases of hyperglycemia in observation group and 32 cases in control group. The detection rate of hyperglycemia in two groups had significant difference (χ2 = 4.95, P <0.05). Fasting blood glucose in observation group, blood glucose level at 2 h after meal were higher than that in control group, but the difference was not statistically significant (P> 0.05). Logistic regression analysis showed that there was a negative correlation between smoking and Parkinson’s disease (P <0.05). The educational level and hyperglycemia at 2 h after meal may be positively correlated with Parkinson’s disease (P <0.05). Conclusion: Hyperglycemia may be related to the occurrence of Parkinson ’s disease. Clinical monitoring and control of fasting blood glucose and 2 - hour postprandial blood glucose may provide a laboratory basis for the prevention and treatment of Parkinson’ s disease.