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目的研究99Tcm-HL91SPECT肺癌显像与病理类型及病灶大小的关系。方法经病理证实的非小细胞肺癌患者共30例,利用SPECT仪采集注射740MBq99Tcm-HL91后2h、4h及6h的前位、后位及侧位平面图像,利用感兴趣区(ROI)技术分别勾画各时相肿瘤(T)和对侧相应部位(N)ROI,计算T/N比值。患者于HL91SPECT检查1周内行CT检查,测量CT图像上病灶大小。结果HL91选择性地浓集于肿瘤组织,浓集区域与CT显示肿瘤区域一致。显像清晰,以4h效果为最佳,2h、4h和6hT/N比值有统计学差异(P=0.041)。鳞癌组及腺癌组4hT/N差异无显著性(P=0.365),病灶大小与T/N无相关关系(Ρ=0.702)。结论99Tcm-HL91显像是一项有价值的肺癌检查手段,而与病理类型及病灶大小无相关性。
Objective To investigate the relationship between 99Tcm-HL91SPECT lung cancer imaging and pathological type and size of lesions. Methods Thirty patients with non-small cell lung cancer confirmed by pathology were enrolled in this study. Anterior, posterior and lateral plane images of 740MBq99Tcm-HL91 were collected by SPECT at 2h, 4h and 6h respectively. ROI The T / N ratio was calculated for each phase tumor (T) and contralateral side (N) ROI. The patient underwent CT examination within 1 week of HL91 SPECT examination to measure the size of the lesion on the CT image. Results HL91 selectively accumulated in tumor tissue, the concentration area and CT showed that the tumor area consistent. 4h and 6hT / N ratio was statistically significant (P = 0.041). There were no significant differences in 4hT / N between squamous cell carcinoma and adenocarcinoma (P = 0.365). There was no correlation between the size of tumor and T / N (P = 0.702). Conclusion 99Tcm-HL91 imaging is a valuable diagnostic tool for lung cancer, but not related to the pathological type and the size of the lesion.