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目的探讨在体质量指数(BMI)正常的蒙古族人群中炎症标志物水平与高血压的关系。方法采用横断面研究的方法,纳入BMI正常的内蒙古通辽市的居民1784人为研究对象,收集各研究对象的基线特征信息,按照血压水平将研究对象分为高血压组(n=583)和血压正常组(n=1201),采集两组研究对象血样并进行血管紧张素Ⅱ(AngⅡ)、高敏C反应蛋白(hsCRP)、可溶性细胞间黏附分子1(sICAM-1)、可溶性E选择素(sE-selectin)的检测。采用协方差分析方法研究炎症标志物水平与血压的关系,采用logistic回归模型分析炎症标志物水平与高血压的关联。结果高血压组的AngⅡ、hsCRP、sICAM-1、sE-selectin水平均高于血压正常组[分别为52.0(40.8,85.9)比47.0(39.3,65.8)ng/L,6.7(4.4,13.7)比5.3(3.5,9.2)mg/L,(334.3±98.0)比(320.1±95.4)μg/L,18.5(15.0,24.4)比17.9(14.1,23.4)μg/L,均P<0.05]。协方差分析结果显示,收缩压与舒张压均随AngⅡ和hsCRP水平增加而升高,线性趋势性检验具有统计学意义。多因素Logistic回归分析表明,AngⅡ,hsCRP水平每升高1个单位,研究对象发生高血压的危险性分别增加至1.005,1.018倍。结论在BMI正常的蒙古族人群中,AngⅡ、hsCRP水平与血压以及高血压相关联。
Objective To investigate the relationship between inflammation markers and hypertension in Mongolian population with normal body mass index (BMI). Methods A total of 1784 inhabitants of Tongliao City, Inner Mongolia with normal BMI, were enrolled in this study. The baseline characteristics of each subject were collected. The subjects were divided into hypertension group (n = 583) and normotensive (N = 1201). Blood samples were collected from two groups of subjects and their plasma levels of angiotensin Ⅱ, hsCRP, sICAM-1, sE- selectin) detection. Covariance analysis was used to investigate the relationship between the level of inflammatory markers and blood pressure. Logistic regression analysis was used to analyze the association between the levels of inflammatory markers and hypertension. Results The levels of AngⅡ, hsCRP, sICAM-1 and sE-selectin in hypertension group were significantly higher than those in normotensive group [52.0 (40.8,85.9) vs 47.0 (39.3,65.8) ng / L, 6.7 (P <0.05). The difference was statistically significant (P <0.05). It was significantly lower than that of the control group (5.3, 3.5, 9.2) mg / L and (334.3 ± 98.0) vs 320.1 ± 95.4 μg / L and 18.5 (15.0 and 24.4) vs 17.9 (14.1 and 23.4) μg / L, respectively. Covariance analysis showed that both systolic and diastolic blood pressure increased with the increase of AngⅡ and hsCRP levels, and the linear trend test was statistically significant. Multivariate Logistic regression analysis showed that for each unit of AngⅡ and hsCRP, the risk of developing hypertension increased to 1.005 and 1.018 times, respectively. Conclusion In Mongolian population with normal BMI, the levels of AngⅡ and hsCRP are associated with blood pressure and hypertension.