论文部分内容阅读
既往悲观的推论认为,急性冠状动脉阻塞意味着受累心肌存活力的永久丧失。目前已为较乐观的希望所取代,即使在数小时后,选择性治疗对于挽救急性缺血心脏组织实际上还是可行的。鉴于文献报道数据常有显著差异,解释上亦有分歧,本文在复习现有证据的基础上,试图对急性心肌缺血和梗塞的各种可能治疗方法加以评述。有争论而待讨论的论题有:(1)目前所用测量心脏缺血的技术及各种治疗措施的效果;(2)实验研究和治疗方案的设计;(3)各种治疗措施的病理生理原理。
Previous pessimistic reasoning suggests that acute coronary occlusion means permanent loss of viable myocardium involvement. It has now been replaced by more optimistic hopes that it is practically feasible to save acute ischemic heart tissue, even hours later. In view of the often significant differences reported in the literature and the differences in interpretation, this review attempts to review various possible treatments for acute myocardial ischemia and infarction based on review of available evidence. Arguments to be discussed are: (1) current techniques used to measure cardiac ischemia and the effects of various treatment measures; (2) experimental research and design of treatment regimens; and (3) pathophysiological principles of various therapeutic measures .