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DL-111,3-(2-苯乙基)-5-(3-甲氧苯-氢1,2,4-三唑)(3-(2-ethylphenyl)-5-(3-methoxyphenyl-1H-1,2,4-triazole),一种由意大利Gruppo Lepetit研究室新合成的非激素,着床后抗生育药。其抗生育作用缓慢,需长时间给药。本研究旨在探讨该药对雄性大鼠体重、睾丸和附性腺重量,核酸和蛋白质含量的影响。用Wistar株21天龄和成年大鼠各20只,前者给DL-111 2.5mg和5.0mg/kg,后者给5 mg和10mg/kg,每天皮下注射1次,连续15天。于给药前和停药后24小时称量体重、睾丸及附性腺重量,组织匀浆提取蛋白质和核酸。实验结果:未成熟大鼠体重、睾丸、附睾、前列腺和精囊重量明显
DL-111 Synthesis of 3- (2-ethylphenyl) -5- (3-methoxyphenyl-1H -1,2,4-triazole), a non-hormonal, post-implantation anti-fertility drug synthesized by the Lepetit Laboratory in Gruppo, Italy, has a slow anti-fertility effect and requires prolonged administration. On body weight, testis and gonadal weight, nucleic acid and protein content in male rats: 21-day-old Wistar strain and 20 adult rats each were given DL-111 2.5 mg and 5.0 mg / kg for the former and 5 mg and 10mg / kg, subcutaneously once a day for 15 days.Weigh the body weight, testis and gonadal weight 24 hours before and after administration, and homogenate to extract protein and nucleic acid.Experimental results: immature Rat weight, testis, epididymis, prostate and seminal vesicle weight