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目的:通过对鼻咽癌患者及其配偶和子女的血清中EB病毒IgA/VCA抗体水平进行分析,进一步了解鼻咽癌患者家属患鼻咽癌的风险情况。方法:选择鼻咽癌患者及其配偶和子女各317例,同一地区正常人群413例,用免疫酶法检测血清中EB病毒IgA/VCA抗体。结果:鼻咽癌组、配偶组、子女组及对照组的IgA/VCA抗体阳性率分别97.2%、14.2%、19.9%及3.1%,鼻咽癌组显著高于其它3组,配偶组和子女组也明显高于对照组(P<0.001)经Ridit分析显示,鼻咽癌组、配偶组、子女组与对照组的平均Ridit值分别为0.860、0.404、0.424及0.356。鼻咽癌组的IgA/VCA抗体滴度水平显著高于其它3组,配偶组和子女组的IgA/VCA抗体滴度水平也明显高于对照组(P<0.001)鼻咽癌患者的配偶与子女IgA/VCA阳性感染的OR值分别为5.09和7.63。配偶组与子女组的IgA/VCA抗体阳性率及抗体滴度水平比较差异均无统计学意义(P>0.05)。结论:EB病毒感染IgA/VCA抗体阳性具有家族聚集性,鼻咽癌患者的配偶及子女EB病毒被再激活的机会要比正常人高,对该高危人群应结合临床密切随访及观察,以便早期发现鼻咽癌。
OBJECTIVE: To investigate the risk of nasopharyngeal carcinoma (NPC) in families with nasopharyngeal carcinoma (NPC) by analyzing the levels of Epstein-Barr virus IgA / VCA antibodies in the serum of NPC patients and their spouses and children. Methods: A total of 317 nasopharyngeal carcinoma patients and their spouses and children were selected, and 413 normal subjects in the same area were selected. Serum EBV IgA / VCA antibody was detected by enzyme immunoassay. Results: The positive rates of IgA / VCA antibody in nasopharyngeal carcinoma group, spouse group, child group and control group were 97.2%, 14.2%, 19.9% and 3.1% respectively, significantly higher in NPC group than in other three groups (P <0.001) Ridit analysis showed that the average Ridit values of nasopharyngeal carcinoma, spouse, children and control group were 0.860,0.404,0.424 and 0.356 respectively. The titer of IgA / VCA antibody in nasopharyngeal carcinoma group was significantly higher than that in the other three groups, and the titer of IgA / VCA antibody in spouses and children group was significantly higher than that in control group (P <0.001) The ORs of children with IgA / VCA positive infection were 5.09 and 7.63, respectively. There was no significant difference in the positive rate of IgA / VCA antibody and antibody titers between spouses and children (P> 0.05). CONCLUSIONS: Epstein-Barr virus (IgA) / VCA antibody positive is familially clustered. The spouses and children with nasopharyngeal carcinoma (EBV) are more likely to have reactivation of Epstein-Barr virus (EBV) than their normal counterparts. This high-risk population should be closely followed and observed clinically for early detection Found nasopharyngeal cancer.