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以对苯乙烯磺酸钠(SSS)为功能单体,以N,N’-亚甲基双丙烯酰胺(MBA)为交联剂,采用铈盐-羟基氧化还原引发体系,在交联聚乙烯醇(CPVA)微球表面实施了5-氟尿嘧啶(5-FU)分子的表面印迹,在微球CPVA表面形成印迹聚合物(MIP)层,即制备了5-FU分子印迹微球MIP-PSSS/CPVA.采用红外光谱(FTIR)和扫描电子显微镜(SEM)法,对印迹微球进行了表征.重点考察分析了印迹微球对5-氟尿嘧啶(5-FU)的结合(载药)性能与结合机理,考察探索了载药微球在不同pH介质中的释放行为.实验结果表明,基于本体系特殊的羟基-铈盐表面引发体系,可有效地实现5-FU分子的表面印迹,在微球CPVA表面形成分布有大量5-FU分子印迹空穴的聚合物层.在酸性介质中,受强静电相互作用的驱动,印迹微球MIP-PSSS/CPVA对5-FU分子表现出很强的结合能力,结合容量达110 mg/g,可实现有效载药.载药微球的释药行为既具有强烈的pH依赖性,又具有时滞性:在模拟胃液中(pH=1),基本不释药;在模拟小肠液中(pH=6.8),释药量很小;在模拟结肠液中(pH=7.4),则发生突释,表现出高效的结肠定位释放行为.
Using sodium p-styrene sulfonate (SSS) as the functional monomer, N, N’-methylenebisacrylamide (MBA) as crosslinking agent and cerium salt-hydroxy redox initiator system, 5-fluorouracil (5-FU) molecule was applied to the surface of alcohol (CPVA) microspheres to form a MIP layer on the surface of microspheres CPVA. That is to say, 5-FU molecularly imprinted microspheres MIP- The imprinted microspheres were characterized by infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), and the binding and drug binding properties of 5-fluorouracil (5-FU) Mechanism, investigate the release behavior of drug-loaded microspheres in different pH media.Experimental results show that the surface of 5-FU molecular imprinting can be effectively achieved based on the special surface-initiated system of hydroxyl-cerium salt, The surface of CPVA formed a polymer layer with a large number of 5-FU molecular imprinting holes distributed.Microspheres MIP-PSSS / CPVA showed a strong binding to 5-FU molecule in acid medium driven by strong electrostatic interaction Ability, the combined capacity of 110 mg / g, can achieve effective drug loading drug-loaded microspheres both with a strong pH-dependent, but also with Sometimes lag: in the simulated gastric fluid (pH = 1), the basic release of drugs; in the simulated intestinal fluid (pH = 6.8), release was small; in simulated colon fluid (pH = 7.4), the sudden Release, showing efficient colonic release behavior.