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在胃食管返流病(GERD)的症状,粘膜病损的发展过程中,胃酸分泌是一个重要的因素。动物实验发现,胃酸分泌亢进是引起食管病理变化的主要异常表现。人体资料也表明很大一部分 GERD患者胃酸分泌亢进,尤其是有 Barrett 上皮者基础胃酸分泌量增加。此外,消除症状和治愈食管炎所需的雷尼替丁,每日剂量与治疗前基础胃酸分泌量显著相关,这说明胃酸分泌亢进可能是许多
Gastric acid secretion is an important factor in the development of symptoms of gastroesophageal reflux disease (GERD) and mucosal lesions. Animal experiments found that gastric acid secretion is caused by pathological changes in esophageal main abnormalities. Human body data also show that a large part of gastric acid secretion in patients with GERD hyperactivity, especially in patients with Barrett’s epithelium increased basal gastric acid secretion. In addition, the daily dose of ranitidine needed to eliminate symptoms and cure esophagitis was significantly correlated with basal gastric acid secretion before treatment, indicating that hypersecretion of gastric acid may be many