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作者应用单克隆抗体检测肝硬化、肝癌病人外周血T淋巴细胞表面受体表达的变化。其中肝硬化(LC)、肝癌(PHC)组的CD_8的阳性细胞分别是34.72％、38.93％,正常对照组为27.30％,与正常组比较,P<0.01。两组CD_4/CD_8比值显著下降,其比值分别为1.29、1.31,正常组1.8,与正常组比较,P<0.01。PHA刺激前,转铁蛋白受体(TFR)和白细胞介素-2受体(IL-2R)在两组患者血中处于高表达状态(P<0.01)。结果提示:抑制性TC升高,TFR以及IL-2R的高表达则直接影响LC和PHC的预后。
The authors used monoclonal antibody to detect the changes of T lymphocyte surface receptor expression in patients with liver cirrhosis and liver cancer. The positive cells of CD_8 in cirrhosis (LC) and hepatocellular carcinoma (PHC) were 34.72% and 38.93% respectively, which was 27.30% in normal control group, P <0.01 compared with normal group. The ratio of CD_4 / CD_8 decreased significantly in both groups, with the ratios of 1.29 and 1.31 respectively, and the normal group was 1.8, P <0.01 compared with the normal group. Before PHA stimulation, transferrin receptor (TFR) and interleukin-2 receptor (IL-2R) were highly expressed in the blood of both groups (P <0.01). The results suggest that elevated TC, TFR and high expression of IL-2R directly affect the prognosis of LC and PHC.