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妊娠妇女２９例于妊娠后期接种乙肝疫苗，观察乙肝疫苗的免疫原性、完全性及胎儿抗体转达情况。追踪观察新生儿出生后乙肝表面抗体阳转率。结果生后１个月抗－ＨＢｓ阳转率８９．６％，生后３个月４抗－ＨＢｓ阳转率８６．３％，生后６个月抗－ＨＢｓ阳转率７５．８％，孕妇接种后抗－ＨＢｓ阳转率６８．９％。说明妊娠后期接种乙肝疫苗有较强的免疫原性。
In the second trimester of pregnancy, 29 pregnant women were inoculated with hepatitis B vaccine to observe the immunogenicity, completeness and fetal antibody transmission of hepatitis B vaccine. Follow-up observation of neonatal hepatitis B surface antibody positive rate of birth. Results The positive rate of anti-HBs was 89.6% at 1 month after birth, the positive rate of anti-HBs was 86.3% at 3 months after birth, the anti-HBs positive rate was 75.8% at 6 months after birth, Anti-HBs positive pregnancy rate 68.9% after inoculation in pregnant women. This shows that hepatitis B vaccination in late pregnancy has strong immunogenicity.