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根据近 30年来作者们发表的剂量监测、流行病学调查和临床 /实验室研究三个方面的成果 ,结合国内外有关报道对云锡矿工肺癌的病因进行总结分析 ,结果肯定了氡在云锡矿工肺癌病因中的贡献和氡 /砷复合致癌作用。现场调查和骨内 2 10 Pb体外测量结果说明 ,氡 /砷累积暴露量的密切相关和早年氡监测数据的欠缺是根据既往流行病学资料估算云锡氡致肺癌危险系数与砷校正系数的干扰因素。对井下砷暴露水平已经明显降低而氡暴露水平仍旧较高的云锡 60年代下井矿工进行长期随访有利于减少这种干扰 ,得到更可信的危险系数估算值。为了对氡 /砷在致癌病因中所占的份额进行估计 ,提出铀矿山对比、肺癌组织发生学研究和氡砷复合动物实验三个途径 ,结果认为云锡矿工肺癌病因是“氡砷复合 ,以氡为主”,粗略估计砷在肺癌病因中的贡献不会超过 1/ 3。本文指出国内外某些作者在砷复合作用校正中存在的问题 ,导致他们对云锡矿工氡致肺癌危险系数估计偏低 ,其结果不适于在我国氡致肺癌的危险控制与预测中使用。利用肺癌危险系数通过病因概率估算完成了包括氡致肺癌在内的我国判断放射性肿瘤的国家标准
According to the results of dose monitoring, epidemiological investigation and clinical/laboratory research published by the authors in the past 30 years, combined with domestic and international reports on the cause of lung cancer in Yunnan tin miners, the results were confirmed. The contribution of miners’ lung cancer etiology and complex carcinogenicity of arsenic and arsenic. Field surveys and in-bone 2 10 Pb in vitro measurements show that the close correlation between cumulative cumulative arsenic and arsenic exposure and lack of monitoring data in early years are based on previous epidemiological data to estimate the risk of lung cancer risk factors and arsenic correction coefficients caused by tin exposure. factor. Long-term follow-up of miners in the Yunxi 60 years who have significantly reduced downhole arsenic exposure but still has high levels of bismuth exposure will help to reduce this interference and obtain more credible estimates of risk factors. In order to estimate the share of tritium/arsenic in the carcinogenic etiology, a comparison of uranium mines, histopathological studies of lung cancer, and arsenic and arsenic compound animal experiments were proposed. The results suggest that the cause of lung cancer in Yunxi miners is “combination of arsenic and arsenic. “The main reason is that”, a rough estimate of the contribution of arsenic in the etiology of lung cancer will not exceed 1/3. This article points out that some authors at home and abroad have problems in the correction of arsenic compounding, leading them to estimate the risk factors for lung cancer risk in Yunnan Tin miners. The results are not suitable for use in the risk control and prediction of lung cancer in China. Using lung cancer risk factors to estimate the national standard for judging radioactive tumors including chymogenic lung cancer by etiological probability estimation