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作者等选用病程已3～34年,年龄19～57岁的哮喘患者,男8女2,一般情况均好,肺X线片无特殊,血嗜酸性白细胞计数有2/3超过300/立方毫米,三年内每人至少有一次超出400/立方毫米,在其发作期间,和每日口服较大剂量的强的松10天后,用稳定状态和单次呼吸法分别测定DLco(肺一氧化碳弥散功能),与它种肺功能检查,并加随访。经强的松治疗后,7例嗜酸性细胞减少7O％,表示激素已有充分疗效。在激素治疗前和治疗平均10周后的肺功能对比,可见FEV(第一秒最大呼气量)与PEF(最大呼气流速)均约增加15％;肺活量显著地由2.72增加到3.72升,TLC(肺总量)虽不变,但残气量却显著减少。PaO_2(动脉血氧张力)平均由74增加到87毫米汞柱,AaPO_2(肺泡动脉血氧张力)由40下降到26毫米汞柱。激素治疗后稳定状态的DLco,由10.6增加到13.6毫升/分钟/毫米汞柱,但这仅占预计值的66.5％;而单次呼吸法的DLco检查平均值,激素治疗前占预计值的144％,治疗后由43.7减少到40.0毫升/分钟毫米汞柱。
Authors selected the duration of 3 to 34 years, aged 19 to 57 years old asthma patients, 8 males and 2, the general situation are good, no special pulmonary X-ray, blood eosinophil count 2/3 more than 300 / cubic millimeter , At least once per person in excess of 400 per cubic millimeter per person for three years, and DLco (Diffusion of Carbon Monoxide Differentiation) at steady state and single breaths during their episodes, and daily oral administration of larger doses of prednisone for 10 days , With its kind of lung function tests, and follow-up. After prednisone treatment, 7 cases of eosinophils decreased 7O%, said the hormone has been fully effective. Lung function contrasts between pretreatment and mean 10 weeks of treatment showed an approximate 15% increase in both FEV (first second maximum expiratory volume) and PEF (maximal expiratory flow); vital capacity increased significantly from 2.72 to 3.72 liters, Although TLC (total lung volume) unchanged, but the residual volume was significantly reduced. PaO2 (arterial oxygen tension) increased from 74 to 87 mmHg on average, while AaPO_2 (alveolar arterial oxygen tension) decreased from 40 to 26 mmHg. The steady-state DLco after hormone therapy increased from 10.6 to 13.6 ml / mmHg, which accounted for only 66.5% of the predicted value, whereas the DLco mean of the single breath method was 144 before the hormone therapy %, Reduced from 43.7 to 40.0 ml / mmHg after treatment.