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目的 :探讨牛磺酸对糖尿病大鼠肾脏氧化和抗氧化系统的影响。方法 :链脲佐菌素 (STZ)诱导糖尿病 (DM)大鼠模型 ,牛磺酸给予DM大鼠 4周后 ,检查肾皮质抗氧化指标超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH -Px)和脂质过氧化物指标丙二醛 (MDA)水平 ,并检测血糖、尿酸及尿白蛋白排泄量。结果 :给予牛磺酸的DM大鼠与DM大鼠血糖水平无差别 ,DM大鼠血尿酸水平及尿白蛋白排泄量明显高于对照组 (P <0 .0 1 ) ,而给予牛磺酸的DM大鼠血尿酸水平下降 (P <0 .0 1 ) ,与正常对照无差别 ,尿白蛋白排泄量也减少 (P <0 .0 5 ) ,但仍高于正常对照 (P <0 .0 1 )。DM大鼠肾皮质SOD和GSH -Px活性均与对照组无明显差别 ,肾皮质MDA水平则明显高于对照组 (P <0 .0 1 ) ;给予牛磺酸的DM大鼠SOD和GSH -Px活性明显高于未处理的DM大鼠及对照组 (P <0 .0 5 ) ,肾皮质MDA水平则明显低于DM大鼠 (P <0 .0 5 ) ,但仍高于对照组 (P <0 .0 5 )。结论 :牛磺酸能增强DM大鼠肾皮质的抗氧化能力 ,减轻DM大鼠肾皮质氧化应激 (OS) ;降低DM大鼠血尿酸水平 ,对其肾脏功能有部分保护作用
Objective: To investigate the effect of taurine on the renal oxidative and anti-oxidative system in diabetic rats. Methods: DM rats were induced by streptozotocin (STZ) and the rats in DM group were given taurine for 4 weeks. The anti-oxidative indexes of renal cortex such as superoxide dismutase (SOD), glutathione (GSH-Px) and malondialdehyde (MDA), a marker of lipid peroxidation, were measured. Blood glucose, uric acid and urinary albumin excretion were measured. Results: There was no difference in blood glucose level between DM rats and DM rats when taurine was administered. Serum uric acid and urinary albumin excretion were significantly higher in DM rats than those in control rats (P <0.01) (P <0.01). The urinary albumin excretion was also decreased (P <0.05), but still higher than that of the normal control (P <0.01). 0 1). The activities of SOD and GSH-PX in the renal cortex of DM rats were not significantly different from those in the control group, while the levels of MDA in renal cortex were significantly higher than those in the control group (P <0.01) Px activity was significantly higher than untreated DM rats and control group (P <0 05), renal cortical MDA levels were significantly lower than DM rats (P <0 05), but still higher than the control group P <0. 05). CONCLUSION: Taurine can enhance the antioxidant capacity of renal cortex in DM rats and decrease the oxidative stress (OS) in diabetic rat renal cortices, and decrease the level of serum uric acid in DM rats and partly protect renal function